cell proliferation inhibition — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2051	SKLB4771	FLT3-IN-1,FLT3-IN-1	FLT
	SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.		FLT
T6831	Etretinate	Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359	Apoptosis , Others
	Etretinate (Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of c...		Apoptosis , Others
T3352	XL413		cholecystokinin , Casein Kinase , Pim , CDK
	XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA ...		cholecystokinin , Casein Kinase , Pim , CDK
T4235	Roblitinib	FGF-401	FGFR
	Roblitinib (FGF-401) is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, Roblitinib binds to and inhibits the activity of FGFR4, which leads ...		FGFR
T72956	Darizmetinib	HRX215	MAPK
	Darizmetinib (HRX215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and li...		MAPK
T6017	Linsitinib	OSI-906	IGF-1R
	OSI-906 (Linsitinib (OSI-906)) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, whic...		IGF-1R
T3623	Cobimetinib	RG7420,XL518,GDC-0973	Apoptosis , MEK
	Cobimetinib (GDC-0973) is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of e...		Apoptosis , MEK
T12831L	SAR405		PI3K , Autophagy
	SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by sta...		PI3K , Autophagy
T2307	Icotinib Hydrochloride	BPI-2009H	EGFR
	Icotinib Hydrochloride (BPI-2009H) is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineoplastic activity. Icotinib selectively inhibits the wild-type ...		EGFR
T1849	Momelotinib	CYT11387,CYT387,LM-1149	Apoptosis , JAK , Autophagy
	Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhib...		Apoptosis , JAK , Autophagy
T5724	Neogambogic acid	neo-gambogic acid	Apoptosis , Others , Antibacterial
	Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect, it may be responsible for the inhibition of proliferation of human breast cancer cell li...		Apoptosis , Others , Antibacterial
TN1516	Cnidicin		NOS , NO Synthase
	Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the pr...		NOS , NO Synthase
T3211	Midostaurin	N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251	Others , PKC
	PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platel...		Others , PKC
T1574	Etoricoxib	Arcoxia,MK-663,Tauxib,L-791456,Nucoxia,Desvenlafaxine	COX
	Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenas...		COX
T6334	Ridaforolimus	AP23573,Deforolimus,MK-8669	mTOR , Autophagy
	Ridaforolimus (AP23573) is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamyc...		mTOR , Autophagy
T11096	DRI-C21045		NF-κB
	Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.Dri-c21045 is an effective selective inhibitor of CD40-CD40L...		NF-κB
T3877	Esculentoside A		NF-κB , COX
	Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmun...		NF-κB , COX
T68405	KW-2450 free base		IGF-1R
	KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free ...		IGF-1R
T50107	Ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate		Others
	ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate is a synthetic compound belonging to the curcumin family. It is involved in the regulation of immune response and inflammation through ...		Others
T5S0527	Rhodojaponin III		Others
	1. Rhodojaponin III has antifeedant and oviposition deterrence effects against many kinds of insects, BdorCSP2 of B. dorsalis could be involved in chemoreception of Rhodojaponin III and played a critical role. 2. Rhodoja...		Others